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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
03/12/2020 |
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Data da última atualização: |
03/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, D. T. da; RODRIGUES, R. F.; MACHADO, N. M.; MAURER, L. H.; FERREIRA, L. F.; SOMACAL, S.; VEIGA, M. L. da; ROCHA, M. I. de U. M. da; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. |
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Afiliação: |
DARIANE TRIVISIOL DA SILVA, UFSM; RENATA FRITZSCHE RODRIGUES, UFSM; NATALIA MINUZZI MACHADO, UFSM; LUANA HASELEIN MAURER, INSTITUTO FEDERAL FARROUPILHA; LAUREN FRESINGHELLI FERREIRA, UFSM; SABRINA SOMACAL, UFSM; MARCELO LEITE DA VEIGA, UFSM; MARIA IZABEL DE UGALDE MARQUES DA ROCHA, UFSM; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES, UFRGS; MILENE TEIXEIRA BARCIA, UFSM; TATIANA EMANUELLI, UFSM. |
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Título: |
Natural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Food Research International , v. 138, Part A, 109718, Dec. 2020. |
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ISSN: |
0963-9969 |
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DOI: |
doi.org/10.1016/j.foodres.2020.109718 |
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Idioma: |
Inglês |
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Conteúdo: |
Blueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain biocompatible extracts of blueberry that exhibit gastroprotective effects with no need of solvent removal. The gastroprotective effects were mainly associated to ARF but NAPF and even NADES vehicle also contributed to some protective effects. MenosBlueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain... Mostrar Tudo |
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Thesagro: |
Extrato; Mirtilo. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/218692/1/Natural-deep-eutectic-solvent.pdf
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Marc: |
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024 7 $adoi.org/10.1016/j.foodres.2020.109718$2DOI
100 1 $aSILVA, D. T. da
245 $aNatural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats.$h[electronic resource]
260 $c2020
520 $aBlueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain biocompatible extracts of blueberry that exhibit gastroprotective effects with no need of solvent removal. The gastroprotective effects were mainly associated to ARF but NAPF and even NADES vehicle also contributed to some protective effects.
650 $aExtrato
650 $aMirtilo
700 1 $aRODRIGUES, R. F.
700 1 $aMACHADO, N. M.
700 1 $aMAURER, L. H.
700 1 $aFERREIRA, L. F.
700 1 $aSOMACAL, S.
700 1 $aVEIGA, M. L. da
700 1 $aROCHA, M. I. de U. M. da
700 1 $aVIZZOTTO, M.
700 1 $aRODRIGUES, E.
700 1 $aBARCIA, M. T.
700 1 $aEMANUELLI, T.
773 $tFood Research International$gv. 138, Part A, 109718, Dec. 2020.
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Registro original: |
Embrapa Clima Temperado (CPACT) |
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| Registros recuperados : 9 | |
| 1. |  | PERTUZATTI, P. B.; BARCIA, M. T.; JACQUES, A. C.; VIZZOTTO, M.; GODOY, H. T.; ZAMBIAZI, R. C. Quantification of several bioactive compounds and antioxidant activities of six cultivars of brazilian blueberry. The Natural Products Journal, v. 2, n. 3, p. 188-195, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: C - 0 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 2. | | LAZZARETTI, M.; MORAES, D. P. de; CAVALHEIRO, S. da S.; ANTUNES, A. C.; RIES, E. F.; WAGNER, R.; VIZZOTTO, M.; BARCIA, M. T. Análises físico-químicas de amora-preta cultivar brs xingu. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS , 12., 2017, Campinas. Ciência de Alimentos e seu Impacto no Mundo em Transformação. Campinas: UNICAMP, 2017. SLACA, 12. De 4 a 7 de Novembro de 2017.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 3. | | MORAES, D. P.; LOZANO-SÁNCHEZ, J.; MACHADO, M. L.; VIZZOTTO, M.; LAZZARETTI, M.; LEYVA-JIMENEZ, F. J. J.; SILVEIRA, T. da; RIES, E. F.; BARCIA, M. T. Characterization of a new blackberry cultivar BRS Xingu: chemical composition, phenolic compounds, and antioxidant capacity in vitro and in vivo. Food Chemistry, v. 322, 126783, Aug. 2020. 9 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 4. | | MORAES, D. P. de; CAVALHEIRO, S. da S.; LAZZARETTI, M.; ANTUNES, A. C.; RIES, E. F.; SMANUELLI, T.; VIZZOTTO, M.; BARCIA, M. T. BRS xingu cultivar: a new blackberry cultivar as potential bioactive compound. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS , 12., 2017, Campinas. Ciência de Alimentos e seu Impacto no Mundo em Transformação. Campinas: UNICAMP, 2017. SLACA, 12. De 4 a 7 de Novembro de 2017.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 5. | | LAZZARETTI, M; MORAES, D. P. de; CAVALHEIRO, S. da S.; ANTUNES, C.; RIES, E. F.; EMANUELLI, T.; VIZZOTTO, M.; BARCIA, M. T. Determinação do Teor de Antocianinas em cultivares de amora-preta. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS , 12., 2017, Campinas. Ciência de Alimentos e seu Impacto no Mundo em Transformação. Campinas: UNICAMP, 2017. SLACA, 12. De 4 a 7 de Novembro de 2017.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 6. | | MORAES, D. P.; CHIM, J. F.; BARIN, J. S.; VIZZOTTO, M.; FARIAS, C. A. A.; BALLUS, C. A.; BARCIA, M. T. Influence of the cultivar on the composition of blackberry (Rubus spp.) minerals. Journal of Food Composition and Analysis, v. 100, 103913, July 2021.| Tipo: Nota Técnica/Nota Científica |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 7. | | SILVA, D. T. da; SMANIOTTO, F. A.; COSTA, I. F.; BARANZELLI, J.; MULLER, A.; SOMACAL, S.; MONTEIRO, C. S.; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. Food Chemistry, v. 364, 130370, Dec. 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 8. | | MORAES, D. P.; MACHADO, M. L.; FARIAS, C. A. A.; BARIN, J. S.; ZABOT, G. L.; LOZANO-SÁNCHEZ, J.; FERREIRA, d. f.; VIZZOTTO, M.; LEYVA-JIMENEZ, F. J.; SILVEIRA, T. L. DA; RIES, E. F.; BARCIA, M. T. Effect of microwave hydrodiffusion and gravity on the extractionof phenolic compounds and antioxidant properties of blackberries (Rubusspp.): scale-Up extraction. Food and Bioprocess Technology, v. 13, p. 2200-2216, 2020. Published online: 20 November 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 9. | | SILVA, D. T. da; RODRIGUES, R. F.; MACHADO, N. M.; MAURER, L. H.; FERREIRA, L. F.; SOMACAL, S.; VEIGA, M. L. da; ROCHA, M. I. de U. M. da; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. Natural deep eutectic solvent (NADES)-based blueberry extracts protect against ethanol-induced gastric ulcer in rats. Food Research International , v. 138, Part A, 109718, Dec. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 9 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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